Developing the next generation of oncolytic immunotherapy.

Replimune is executing a broad, aggressive development plan with a pipeline of potent oncolytic immunotherapies now entering clinical studies for multiple types of cancer. Our goal is to realize the potential of our Immulytic™ platform to treat a wide range of solid tumors, including ‘immunologically cold’ tumor types.

RP1 is our first Immulytic™ product to enter the clinic,

We have initiated a large Phase 1/2 clinical trial of RP1 alone and in combination with checkpoint blockade across several tumor types.

RP2 & RP3
RP2 and RP3 are derivatives of RP1 that express additional proteins. RP2 expresses an anti-CTLA-4 antibody-like molecule and RP3 additionally expresses optimized immune co-stimulatory pathway ligands. These therapeutics provide targeted delivery to the sites of immune response initiation in the tumor and draining lymph nodes with the goal of focusing systemic immune-based efficacy on tumors and limiting off target toxicity.